The San Francisco 49ers head north to face the Seattle Seahawks at Lumen Field this afternoon in a Week 1 divisional clash.
San Francisco enters the season with a renewed defensive push under Robert Saleh, aiming to rebound from last year’s 6–11 finish.
QB Brock Purdy, healthy and firmly entrenched as the starter, looks to build on his steady growth and command of Kyle Shanahan’s system. All-Pro RB Christian McCaffrey, listed as questionable earlier in the week with calf tightness, is expected to play and provide stability to the offense.
On the other side, Seattle debuts new QB Sam Darnold, who now has WR Cooper Kupp as a top target, giving the Seahawks’ passing attack a fresh look as the franchise marks its 50th season at home.
The 49ers must pressure Darnold early, as his efficiency drops under duress, completing just around half of passes when pressured.
Third-down defense will also be decisive: San Francisco ranked 24th in that category last season, while Seattle thrived in extending drives.
Expect Shanahan to get creative with McCaffrey and TE George Kittle, utilizing heavy personnel groupings and possibly splitting snaps with Brian Robinson Jr.
The Seahawks’ defensive depth could make a difference, as veterans Quinton Bohanna and Shaquill Griffin have been elevated to reinforce the front line.
Predictions
The 49ers have a more established identity overall, especially in the trenches and offensively with McCaffrey active. Seattle’s new arrangement offers intrigue, but transitioning under a new QB and scheme may delay fluidity in Week 1. Expect the 49ers to control tempo and offensive consistency.
Projected Final Score: 49ers 24, Seahawks 17
Injury Report
San Francisco 49ers
RB Jordan James — Out (finger)
DL Jordan Watkins — Out (ankle)
Seattle Seahawks
WR Dareke Young — Out (hamstring)
LB Uchenna Nwosu — Out (knee)
WR Jake Bobo — Out (concussion)
How to Watch 49ers vs. Seahawks
This afternoon’s game between the San Francisco 49ers and Seattle Seahawks kicks off at 4:05 PM Eastern / 1:05 PM Pacific at Lumen Field.
The game airs live regionally on FOX, with streaming available on the FOX Sports app and website.
Fans outside those regions can watch on YouTube’s NFL Sunday Ticket, starting at $34.50 per month.
Not ready to commit? Services like FuboTV, YouTube TV, Hulu + Live TV, and DirecTV Stream all offer free trial periods that include local FOX broadcasts. YouTube TV also provides a 20-minute free preview without requiring registration.
San Francisco 49ers vs. Seattle Seahawks
Date: Sunday, September 7, 2025
Time: 4:05 PM Eastern / 1:05 P Pacific
Venue: Lumen Field, Seattle, WA
TV: FOX
Streaming: FOX Sports app and website, NFL+, YouTube NFL Sunday Ticket
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